Conformational Equilibrium of NADPH–Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH–cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...

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Detalhes bibliográficos
Publicado no:Antioxidants (Basel)
Main Authors: Sugishima, Masakazu, Taira, Junichi, Sagara, Tatsuya, Nakao, Ryota, Sato, Hideaki, Noguchi, Masato, Fukuyama, Keiichi, Yamamoto, Ken, Yasunaga, Takuo, Sakamoto, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464098/
https://ncbi.nlm.nih.gov/pubmed/32731542
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/antiox9080673
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