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Structural Features Defining NF-κB Inhibition by Lignan-Inspired Benzofurans and Benzothiophenes

A series of 2-arylbenzofurans and 2-arylbenzothiophenes was synthesized carrying three different side chains in position five. The synthesized compounds were tested for NF-κB inhibition to establish a structure activity relationship. It was found that both, the side chain in position five and the su...

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Bibliografiske detaljer
Udgivet i:Biomolecules
Main Authors: Dao-Huy, Toan, Latkolik, Simone, Bräuer, Julia, Pfeil, Andreas, Stuppner, Hermann, Schnürch, Michael, Dirsch, Verena M., Mihovilovic, Marko D.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463992/
https://ncbi.nlm.nih.gov/pubmed/32751917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom10081131
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