Leoligin-inspired synthetic lignans with selectivity for cell-type and bioactivity relevant for cardiovascular disease

Recently, a natural compound leoligin, a furan-type lignan, was discovered as an interesting hit compound with an anti-inflammatory pharmacological activity profile. We developed a modular and stereoselective approach for the synthesis of the edelweiss-derived lignan leoligin and used the synthetic...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Linder, Thomas, Liu, Rongxia, Atanasov, Atanas G., Li, Yuanfang, Geyrhofer, Sophie, Schwaiger, Stefan, Stuppner, Hermann, Schnürch, Michael, Dirsch, Verena M., Mihovilovic, Marko D.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2019
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6568278/
https://ncbi.nlm.nih.gov/pubmed/31293770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9sc00446g
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