Linked magnolol dimer as a selective PPARγ agonist – Structure-based rational design, synthesis, and bioactivity evaluation

The nuclear receptors peroxisome proliferator-activated receptor γ (PPARγ) and its hetero-dimerization partner retinoid X receptor α (RXRα) are considered as drug targets in the treatment of diseases like the metabolic syndrome and diabetes mellitus type 2. Effort has been made to develop new agonis...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Dreier, Dominik, Latkolik, Simone, Rycek, Lukas, Schnürch, Michael, Dymáková, Andrea, Atanasov, Atanas G., Ladurner, Angela, Heiss, Elke H., Stuppner, Hermann, Schuster, Daniela, Mihovilovic, Marko D., Dirsch, Verena M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5651862/
https://ncbi.nlm.nih.gov/pubmed/29057944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12628-5
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