The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations

Fluorinated glycomimetics are frequently employed to study and eventually modulate protein–glycan interactions. However, complex glycans and their glycomimetics may display multiple binding epitopes that enormously complicate the access to a complete picture of the protein–ligand complexes. We herei...

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Bibliographic Details
Published in:Pharmaceuticals (Basel)
Main Authors: Martínez, J. Daniel, Infantino, Angela S., Valverde, Pablo, Diercks, Tammo, Delgado, Sandra, Reichardt, Niels-Christian, Ardá, Ana, Cañada, Francisco Javier, Oscarson, Stefan, Jiménez-Barbero, Jesús
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463913/
https://ncbi.nlm.nih.gov/pubmed/32759765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph13080179
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