The Interaction of Fluorinated Glycomimetics with DC-SIGN: Multiple Binding Modes Disentangled by the Combination of NMR Methods and MD Simulations

Fluorinated glycomimetics are frequently employed to study and eventually modulate protein–glycan interactions. However, complex glycans and their glycomimetics may display multiple binding epitopes that enormously complicate the access to a complete picture of the protein–ligand complexes. We herei...

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Pubblicato in:Pharmaceuticals (Basel)
Autori principali: Martínez, J. Daniel, Infantino, Angela S., Valverde, Pablo, Diercks, Tammo, Delgado, Sandra, Reichardt, Niels-Christian, Ardá, Ana, Cañada, Francisco Javier, Oscarson, Stefan, Jiménez-Barbero, Jesús
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463913/
https://ncbi.nlm.nih.gov/pubmed/32759765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph13080179
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