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SUMOylation modulates the LIN28A‐let‐7 signaling pathway in response to cellular stresses in cancer cells

LIN28A is a conserved RNA‐binding protein that inhibits the biogenesis of let‐7 microRNAs, thus promoting cancer progression. However, mechanisms underlying the activation of the LIN28A‐let‐7 signaling pathway remain poorly understood. Here, we show that LIN28A is SUMOylated in vivo and in vitro at...

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Bibliografski detalji
Izdano u:Mol Oncol
Glavni autori: Dou, Jinzhuo, Zhang, Hailong, Chen, Ran, Shu, Zimei, Yuan, Haihua, Zhao, Xian, Wang, Yanli, Huang, Jian, Zhou, Aiwu, Yu, Jianxiu
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463354/
https://ncbi.nlm.nih.gov/pubmed/32333719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12694
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