SUMOylation modulates the LIN28A‐let‐7 signaling pathway in response to cellular stresses in cancer cells

LIN28A is a conserved RNA‐binding protein that inhibits the biogenesis of let‐7 microRNAs, thus promoting cancer progression. However, mechanisms underlying the activation of the LIN28A‐let‐7 signaling pathway remain poorly understood. Here, we show that LIN28A is SUMOylated in vivo and in vitro at...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Oncol
Egile Nagusiak: Dou, Jinzhuo, Zhang, Hailong, Chen, Ran, Shu, Zimei, Yuan, Haihua, Zhao, Xian, Wang, Yanli, Huang, Jian, Zhou, Aiwu, Yu, Jianxiu
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2020
Gaiak:
Research Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463354/
https://ncbi.nlm.nih.gov/pubmed/32333719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12694
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