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Using serpins cysteine protease cross-specificity to possibly trap SARS-CoV-2 Mpro with reactive center loop chimera

Human serine protease inhibitors (serpins) are the main inhibitors of serine proteases, but some of them also have the capability to effectively inhibit cysteine proteases. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) main protease (Mpro) is a chymotrypsin-type cysteine protease that...

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Detalhes bibliográficos
Publicado no:Clin Sci (Lond)
Main Authors: Jairajpuri, Mohamad Aman, Ansari, Shoyab
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463295/
https://ncbi.nlm.nih.gov/pubmed/32869854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/CS20200767
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