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Heparin Enhances Serpin Inhibition of the Cysteine Protease Cathepsin L

The glycosaminoglycan heparin is known to possess antimetastatic activity in experimental models and preclinical studies, but there is still uncertainty over its mechanism of action in this respect. As an anticoagulant, heparin enhances inhibition of thrombin by the serpin antithrombin III, but a si...

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Detalhes bibliográficos
Main Authors: Higgins, Wayne J., Fox, Denise M., Kowalski, Piotr S., Nielsen, Jens E., Worrall, D. Margaret
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823513/
https://ncbi.nlm.nih.gov/pubmed/19959474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.037358
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