Differential therapeutic effects of PARP and ATR inhibition combined with radiotherapy in the treatment of subcutaneous versus orthotopic lung tumour models

BACKGROUND: Subcutaneous mouse tumour models are widely used for the screening of novel antitumour treatments, although these models are poor surrogate models of human cancers. METHODS: We compared the antitumour efficacy of the combination of ionising radiation (IR) with two DNA damage response inh...

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Détails bibliographiques
Publié dans:Br J Cancer
Auteurs principaux: Tran Chau, Vanessa, Liu, Winchygn, Gerbé de Thoré, Marine, Meziani, Lydia, Mondini, Michele, O’Connor, Mark J., Deutsch, Eric, Clémenson, Céline
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7463250/
https://ncbi.nlm.nih.gov/pubmed/32546832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-020-0931-6
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