TGFβ receptor inhibition unleashes interferon-β production by tumor-associated macrophages and enhances radiotherapy efficacy

Background Transforming growth factor-beta (TGFβ) can limit the efficacy of cancer treatments, including radiotherapy (RT), by inducing an immunosuppressive tumor environment. The association of TGFβ with impaired T cell infiltration and antitumor immunity is known, but the mechanisms by which TGFβ...

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Detalles Bibliográficos

Principais autores:	Eric Deutsch, Michele Mondini, Nicolas Signolle, Pauline Hamon, Marine Gerbé De Thoré, Marion Classe, Winchygn Liu, Olivia Bawa, Lydia Meziani, Céline Clémenson, Fabien Milliat
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMJ Publishing Group 2022-03-01
Series:	Journal for ImmunoTherapy of Cancer
Acceso en liña:	https://jitc.bmj.com/content/10/3/e003519.full
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