Non-homogenous intratumor ionizing radiation doses synergize with PD1 and CXCR2 blockade

Abstract The efficacy and side effects of radiotherapy (RT) depend on parameters like dose and the volume of irradiated tissue. RT induces modulations of the tumor immune microenvironment (TIME) that are dependent on the dose. Low dose RT (LDRT, i.e., single doses of 0.5–2 Gy) has been shown to prom...

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Hauptverfasser:	Paul Bergeron, Morgane Dos Santos, Lisa Sitterle, Georges Tarlet, Jeremy Lavigne, Winchygn Liu, Marine Gerbé de Thoré, Céline Clémenson, Lydia Meziani, Cathyanne Schott, Giulia Mazzaschi, Kevin Berthelot, Mohamed Amine Benadjaoud, Fabien Milliat, Eric Deutsch, Michele Mondini
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-10-01
Schriftenreihe:	Nature Communications
Online-Zugang:	https://doi.org/10.1038/s41467-024-53015-9
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