MicroRNA-3148 acts as molecular switch promoting malignant transformation and adipocytic differentiation of immortalized human bone marrow stromal cells via direct targeting of the SMAD2/TGFβ pathway

MicroRNAs (miRs/miRNAs) play a key role in posttranscriptional regulation of gene expression and are implicated in a number of physiological and pathological conditions, including cellular malignant transformation. In the current study, we investigated the role of miR-3148 in regulating human stroma...

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Publicat a:Cell Death Discov
Autors principals: Vishnubalaji, Radhakrishnan, Elango, Ramesh, Manikandan, Muthurangan, Siyal, Abdul-Aziz, Ali, Dalia, Al-Rikabi, Ammar, Hamam, Dana, Hamam, Rimi, Benabdelkamel, Hicham, Masood, Afshan, Alanazi, Ibrahim O., Alfadda, Assim A., Alfayez, Musaad, Aldahmash, Abdullah, Kassem, Moustapha, Alajez, Nehad M.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7462980/
https://ncbi.nlm.nih.gov/pubmed/32922961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-00312-z
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