Additive and Multiplicative Interactions Between Genetic Risk Score and Family History and Lifestyle in Relation to Risk of Type 2 Diabetes

We examined interactions between lifestyle factors and genetic risk of type 2 diabetes (T2D-GR), captured by genetic risk score (GRS) and family history (FH). Our initial study cohort included 20,524 European-ancestry participants, of whom 1,897 developed incident T2D, in the Nurses’ Health Study (1...

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Bibliografiske detaljer
Udgivet i:Am J Epidemiol
Main Authors: Ding, Ming, Ahmad, Shafqat, Qi, Lu, Hu, Yang, Bhupathiraju, Shilpa N, Guasch-Ferré, Marta, Jensen, Majken K, Chavarro, Jorge E, Ridker, Paul M, Willett, Walter C, Chasman, Daniel I, Hu, Frank B, Kraft, Peter
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
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Original Contribution
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7462250/
https://ncbi.nlm.nih.gov/pubmed/31647510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/aje/kwz251
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