Key Players in the Mutant p53 Team: Small Molecules, Gene Editing, Immunotherapy

The transcription factor p53 is a key tumor suppressor that is inactivated in almost all cancers due to either point mutations in the TP53 gene or overexpression of its negative regulators. The p53 protein is known as the “cellular gatekeeper” for its roles in facilitating DNA repair, cell cycle arr...

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Dettagli Bibliografici
Pubblicato in:Front Oncol
Autori principali: Chasov, Vitaly, Mirgayazova, Regina, Zmievskaya, Ekaterina, Khadiullina, Raniya, Valiullina, Aygul, Stephenson Clarke, Joseph, Rizvanov, Albert, Baud, Matthias G. J., Bulatov, Emil
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461930/
https://ncbi.nlm.nih.gov/pubmed/32974171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.01460
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