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Therapeutic Editing of the TP53 Gene: Is CRISPR/Cas9 an Option?
The TP53 gene encodes the transcription factor and oncosuppressor p53 protein that regulates a multitude of intracellular metabolic pathways involved in DNA damage repair, cell cycle arrest, apoptosis, and senescence. In many cases, alterations (e.g., mutations of the TP53 gene) negatively affect th...
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| Udgivet i: | Genes (Basel) |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
MDPI
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7349023/ https://ncbi.nlm.nih.gov/pubmed/32630614 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes11060704 |
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