Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions

BACKGROUND: Cytidine base editors (CBEs), composed of a cytidine deaminase fused to Cas9 nickase (nCas9), enable efficient C-to-T conversion in various organisms. However, current base editors can induce unwanted bystander C-to-T conversions when multiple Cs are present in the ~ 5-nucleotide activit...

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Veröffentlicht in:BMC Biol
Hauptverfasser: Liu, Zhiquan, Chen, Siyu, Shan, Huanhuan, Jia, Yingqi, Chen, Mao, Song, Yuning, Lai, Liangxue, Li, Zhanjun
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461344/
https://ncbi.nlm.nih.gov/pubmed/32867757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00849-6
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