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Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions
BACKGROUND: Cytidine base editors (CBEs), composed of a cytidine deaminase fused to Cas9 nickase (nCas9), enable efficient C-to-T conversion in various organisms. However, current base editors can induce unwanted bystander C-to-T conversions when multiple Cs are present in the ~ 5-nucleotide activit...
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| Publicado no: | BMC Biol |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7461344/ https://ncbi.nlm.nih.gov/pubmed/32867757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-020-00849-6 |
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