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Efficient base editing with high precision in rabbits using YFE-BE4max
Cytidine base editors, composed of a cytidine deaminase fused to Cas9 nickase, enable efficient C-to-T conversion in various organisms. However, current base editors suffer from severe trade-off between editing efficiency and precision. Here, based on rationally mutated cytidine deaminase domain, we...
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| Publicado no: | Cell Death Dis |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6971250/ https://ncbi.nlm.nih.gov/pubmed/31959743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2244-3 |
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