The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes

Idiopathic pulmonary fibrosis (IPF) is a chronic disease for which novel approaches are urgently required. We reported increased sphingosine kinase 1 (SPHK1) in IPF lungs and that SPHK1 inhibition using genetic and pharmacologic approaches reduces murine bleomycin-induced pulmonary fibrosis. We dete...

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Detalhes bibliográficos
Publicado no:Int J Mol Sci
Main Authors: Cheresh, Paul, Kim, Seok-Jo, Huang, Long Shuang, Watanabe, Satoshi, Joshi, Nikita, Williams, Kinola J.N., Chi, Monica, Lu, Ziyan, Harijith, Anantha, Yeldandi, Anjana, Lam, Anna P., Gottardi, Cara, Misharin, Alexander V., Budinger, G.R. Scott, Natarajan, Viswanathan, Kamp, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7460639/
https://ncbi.nlm.nih.gov/pubmed/32764262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21165595
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