The Sphingosine Kinase 1 Inhibitor, PF543, Mitigates Pulmonary Fibrosis by Reducing Lung Epithelial Cell mtDNA Damage and Recruitment of Fibrogenic Monocytes

Idiopathic pulmonary fibrosis (IPF) is a chronic disease for which novel approaches are urgently required. We reported increased sphingosine kinase 1 (SPHK1) in IPF lungs and that SPHK1 inhibition using genetic and pharmacologic approaches reduces murine bleomycin-induced pulmonary fibrosis. We dete...

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Publicado en:Int J Mol Sci
Autores principales: Cheresh, Paul, Kim, Seok-Jo, Huang, Long Shuang, Watanabe, Satoshi, Joshi, Nikita, Williams, Kinola J.N., Chi, Monica, Lu, Ziyan, Harijith, Anantha, Yeldandi, Anjana, Lam, Anna P., Gottardi, Cara, Misharin, Alexander V., Budinger, G.R. Scott, Natarajan, Viswanathan, Kamp, David W.
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7460639/
https://ncbi.nlm.nih.gov/pubmed/32764262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21165595
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