Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome

Epithelial Ovarian cancer (EOC) is the most lethal gynecological malignancy and has limited curative therapeutic options. Immunotherapy for EOC is promising, but clinical efficacy remains restricted to a small percentage of patients. Several lines of evidence suggest that the low response rate might...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Brunekreeft, Kim L., Paijens, Sterre T., Wouters, Maartje C.A., Komdeur, Fenne L., Eggink, Florine A., Lubbers, Joyce M., Workel, Hagma H., Van Der Slikke, Elisabeth C., Pröpper, Noor E.J., Leffers, Ninke, Adam, Julien, Pijper, Harry, Plat, Annechien, Kol, Arjan, Nijman, Hans W., De Bruyn, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458665/
https://ncbi.nlm.nih.gov/pubmed/32923120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1760705
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