Deep immune profiling of ovarian tumors identifies minimal MHC-I expression after neoadjuvant chemotherapy as negatively associated with T-cell-dependent outcome

Epithelial Ovarian cancer (EOC) is the most lethal gynecological malignancy and has limited curative therapeutic options. Immunotherapy for EOC is promising, but clinical efficacy remains restricted to a small percentage of patients. Several lines of evidence suggest that the low response rate might...

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Bibliografiske detaljer
Udgivet i:Oncoimmunology
Main Authors: Brunekreeft, Kim L., Paijens, Sterre T., Wouters, Maartje C.A., Komdeur, Fenne L., Eggink, Florine A., Lubbers, Joyce M., Workel, Hagma H., Van Der Slikke, Elisabeth C., Pröpper, Noor E.J., Leffers, Ninke, Adam, Julien, Pijper, Harry, Plat, Annechien, Kol, Arjan, Nijman, Hans W., De Bruyn, Marco
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2020
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458665/
https://ncbi.nlm.nih.gov/pubmed/32923120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1760705
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