The metabolic enzyme arginase-2 is a potential target for novel immune modulatory vaccines

One way that tumors evade immune destruction is through tumor and stromal cell expression of arginine-degrading enzyme arginase-2 (ARG2). Here we describe the existence of pro-inflammatory effector T-cells that recognize ARG2 and can directly target tumor and tumor-infiltrating cells. Using a librar...

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Detalles Bibliográficos
Publicado en:Oncoimmunology
Main Authors: Weis-Banke, Stine Emilie, Hübbe, Mie Linder, Holmström, Morten Orebo, Jørgensen, Mia Aaboe, Bendtsen, Simone Kloch, Martinenaite, Evelina, Carretta, Marco, Svane, Inge Marie, Ødum, Niels, Pedersen, Ayako Wakatsuki, Met, Özcan, Madsen, Daniel Hargbøl, Andersen, Mads Hald
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2020
Assuntos:
Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458644/
https://ncbi.nlm.nih.gov/pubmed/32923127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2020.1771142
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