Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels

Kv2.1 channels mediate cell death–enabling loss of cytosolic potassium in neurons following plasma membrane insertion at somatodendritic clusters. Overexpression of the carboxyl terminus (CT) of the cognate channel Kv2.2 is neuroprotective by disrupting Kv2.1 surface clusters. Here, we define a seve...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Adv
Auteurs principaux: Schulien, Anthony J., Yeh, Chung-Yang, Orange, Bailey N., Pav, Olivia J., Hopkins, Madelynn P., Moutal, Aubin, Khanna, Rajesh, Sun, Dandan, Justice, Jason A., Aizenman, Elias
Format: Artigo
Langue:Inglês
Publié: American Association for the Advancement of Science 2020
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458461/
https://ncbi.nlm.nih.gov/pubmed/32937450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz8110
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