Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischemic stroke in mice by declustering Kv2.1 channels

Kv2.1 channels mediate cell death–enabling loss of cytosolic potassium in neurons following plasma membrane insertion at somatodendritic clusters. Overexpression of the carboxyl terminus (CT) of the cognate channel Kv2.2 is neuroprotective by disrupting Kv2.1 surface clusters. Here, we define a seve...

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Bibliografiska uppgifter
I publikationen:Sci Adv
Huvudupphovsmän: Schulien, Anthony J., Yeh, Chung-Yang, Orange, Bailey N., Pav, Olivia J., Hopkins, Madelynn P., Moutal, Aubin, Khanna, Rajesh, Sun, Dandan, Justice, Jason A., Aizenman, Elias
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Association for the Advancement of Science 2020
Ämnen:
Research Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458461/
https://ncbi.nlm.nih.gov/pubmed/32937450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz8110
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