Defining the Kv2.1–syntaxin molecular interaction identifies a first-in-class small molecule neuroprotectant

The neuronal cell death-promoting loss of cytoplasmic K(+) following injury is mediated by an increase in Kv2.1 potassium channels in the plasma membrane. This phenomenon relies on Kv2.1 binding to syntaxin 1A via 9 amino acids within the channel intrinsically disordered C terminus. Preventing this...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Yeh, Chung-Yang, Ye, Zhaofeng, Moutal, Aubin, Gaur, Shivani, Henton, Amanda M., Kouvaros, Stylianos, Saloman, Jami L., Hartnett-Scott, Karen A., Tzounopoulos, Thanos, Khanna, Rajesh, Aizenman, Elias, Camacho, Carlos J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6681760/
https://ncbi.nlm.nih.gov/pubmed/31308225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1903401116
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