Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1

The NMDA receptor (NMDAR) is inhibited by synaptically released zinc. This inhibition is thought to be the result of zinc diffusion across the synaptic cleft and subsequent binding to the extracellular domain of the NMDAR. However, this model fails to incorporate the observed association of the high...

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Publicat a:Sci Adv
Autors principals: Krall, Rebecca F., Moutal, Aubin, Phillips, Matthew B., Asraf, Hila, Johnson, Jon W., Khanna, Rajesh, Hershfinkel, Michal, Aizenman, Elias, Tzounopoulos, Thanos
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458442/
https://ncbi.nlm.nih.gov/pubmed/32937457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb1515
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