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Synaptic zinc inhibition of NMDA receptors depends on the association of GluN2A with the zinc transporter ZnT1

The NMDA receptor (NMDAR) is inhibited by synaptically released zinc. This inhibition is thought to be the result of zinc diffusion across the synaptic cleft and subsequent binding to the extracellular domain of the NMDAR. However, this model fails to incorporate the observed association of the high...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Adv
Main Authors: Krall, Rebecca F., Moutal, Aubin, Phillips, Matthew B., Asraf, Hila, Johnson, Jon W., Khanna, Rajesh, Hershfinkel, Michal, Aizenman, Elias, Tzounopoulos, Thanos
פורמט: Artigo
שפה:Inglês
יצא לאור: American Association for the Advancement of Science 2020
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458442/
https://ncbi.nlm.nih.gov/pubmed/32937457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abb1515
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