Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro

Flaviviruses, such as Dengue (DENV) and Zika (ZIKV) viruses, represent a severe health burden. There are currently no FDA-approved treatments, and vaccines against most flaviviruses are still lacking. We have developed several flexible analogues (“fleximers”) of the FDA-approved nucleoside Acyclovir...

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Udgivet i:Bioorg Med Chem
Main Authors: Thames, Joy E., Waters, Charles D., Valle, Coralie, Bassetto, Marcella, Aouadi, Wahiba, Martin, Baptiste, Selisko, Barbara, Falat, Arissa, Coutard, Bruno, Brancale, Andrea, Canard, Bruno, Decroly, Etienne, Seley-Radtke, Katherine L.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier Ltd. 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457965/
https://ncbi.nlm.nih.gov/pubmed/33128910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115713
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