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AMPK/mTOR/ULK1 Axis-Mediated Pathway Participates in Apoptosis and Autophagy Induction by Oridonin in Colon Cancer DLD-1 Cells

BACKGROUND: Oridonin has been demonstrated to exert strong antitumor activities in various types of human cancers. Our previous study established that oridonin induced the apoptosis of and exerted an inhibitory effect on colon cancer cells in vitro and in vivo. However, the mechanisms behind the ant...

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Vydáno v:Onco Targets Ther
Hlavní autoři: Bu, Heqi, Liu, Dianlei, Zhang, Guolin, Chen, Li, Song, Zhangfa
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457577/
https://ncbi.nlm.nih.gov/pubmed/32904616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S262022
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