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AMPK/mTOR/ULK1 Axis-Mediated Pathway Participates in Apoptosis and Autophagy Induction by Oridonin in Colon Cancer DLD-1 Cells

BACKGROUND: Oridonin has been demonstrated to exert strong antitumor activities in various types of human cancers. Our previous study established that oridonin induced the apoptosis of and exerted an inhibitory effect on colon cancer cells in vitro and in vivo. However, the mechanisms behind the ant...

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Detalhes bibliográficos
Publicado no:Onco Targets Ther
Main Authors: Bu, Heqi, Liu, Dianlei, Zhang, Guolin, Chen, Li, Song, Zhangfa
Formato: Artigo
Idioma:Inglês
Publicado em: Dove 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457577/
https://ncbi.nlm.nih.gov/pubmed/32904616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S262022
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