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Ferroptosis inhibitor, liproxstatin-1, protects the myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and rescuing GPX4 levels

Ferroptosis is a distinct iron-dependent mechanism of regulated cell death recognized in cancer and ischemia/reperfusion (I/R) injury of different organs. It has been reported that molecules such as liproxstatin-1 (Lip-1) inhibit ferroptosis and promote cell survival however, the mechanisms underlyi...

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Bibliografische gegevens
Gepubliceerd in:Biochem Biophys Res Commun
Hoofdauteurs: Feng, Yansheng, Madungwe, Ngonidzashe B., Imam Aliagan, Abdulhafiz D., Tombo, Nathalie, Bopassa, Jean C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457545/
https://ncbi.nlm.nih.gov/pubmed/31623831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2019.10.006
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