CNS axonal degeneration and transport deficits at the optic nerve head precede structural and functional loss of retinal ganglion cells in a mouse model of glaucoma

BACKGROUND: Glaucoma is a leading neurodegenerative disease affecting over 70 million individuals worldwide. Early pathological events of axonal degeneration and retinopathy in response to elevated intraocular pressure (IOP) are limited and not well-defined due to the lack of appropriate animal mode...

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Publicat a:Mol Neurodegener
Autors principals: Maddineni, Prabhavathi, Kasetti, Ramesh B., Patel, Pinkal D., Millar, J. Cameron, Kiehlbauch, Charles, Clark, Abbot F., Zode, Gulab S.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457267/
https://ncbi.nlm.nih.gov/pubmed/32854767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-020-00400-9
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