Tumor Necrosis Factor Overcomes Immune Evasion in p53-Mutant Medulloblastoma

Many immunotherapies act by enhancing the ability of cytotoxic T cells to kill tumor cells. Killing depends on T cell recognition of antigens presented by class I major histocompatibility complex (MHC-I) proteins on tumor cells. Here we show that medulloblastomas lacking the p53 tumor suppressor do...

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Publicado no:Nat Neurosci
Main Authors: Garancher, Alexandra, Suzuki, Hiromichi, Haricharan, Svasti, Chau, Lianne Q., Masihi, Meher Beigi, Rusert, Jessica M., Norris, Paula S., Carrette, Florent, Romero, Megan M., Morrissy, Sorana A., Skowron, Patryk, Cavalli, Florence M.G., Farooq, Hamza, Ramaswamy, Vijay, Jones, Steven J.M., Moore, Richard A., Mungall, Andrew J., Ma, Yussanne, Thiessen, Nina, Li, Yisu, Morcavallo, Alaide, Qi, Lin, Kogiso, Mari, Du, Yuchen, Baxter, Patricia, Henderson, Jacob J., Crawford, John R., Levy, Michael L., Olson, James M., Cho, Yoon-Jae, Deshpande, Aniruddha J., Li, Xiao-Nan, Chesler, Louis, Marra, Marco A., Wajant, Harald, Becher, Oren J., Bradley, Linda M., Ware, Carl F., Taylor, Michael D., Wechsler-Reya, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456619/
https://ncbi.nlm.nih.gov/pubmed/32424282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-020-0628-4
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