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Butenolide synthesis from functionalized cyclopropenones

A general method to synthesize substituted butenolides from hydroxymethylcyclopropenones is reported. Functionalized cyclopropenones undergo ring-opening reactions with catalytic amounts of phosphine, forming reactive ketene ylides. These intermediates can be trapped by pendant hydroxy groups to aff...

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Bibliografske podrobnosti
izdano v:Org Lett
Main Authors: Nguyen, Sean S., Ferreira, Andrew J., Long, Zane G., Heiss, Tyler K., Dorn, Robert S., Row, R. David, Prescher, Jennifer A.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456522/
https://ncbi.nlm.nih.gov/pubmed/31622107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.9b03298
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