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Chemically triggered crosslinking with bioorthogonal cyclopropenones
We report a proximity-driven crosslinking strategy featuring bioorthogonal cyclopropenones. These motifs react with phosphines to form electrophilic ketene-ylides. Such intermediates can be trapped by neighboring proteins to form covalent adducts. Successful crosslinking was achieved using a model s...
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| Publicat a: | Chem Commun (Camb) |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7501174/ https://ncbi.nlm.nih.gov/pubmed/32808608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0cc04600k |
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