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Nucleosome allostery in pioneer transcription factor binding

While recent experiments revealed that some pioneer transcription factors (TFs) can bind to their target DNA sequences inside a nucleosome, the binding dynamics of their target recognitions are poorly understood. Here we used the latest coarse-grained models and molecular dynamics simulations to stu...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Tan, Cheng, Takada, Shoji
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456188/
https://ncbi.nlm.nih.gov/pubmed/32778600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2005500117
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