Structural elucidation of the cis-prenyltransferase NgBR/DHDDS complex reveals insights in regulation of protein glycosylation

Cis-prenyltransferase (cis-PTase) catalyzes the rate-limiting step in the synthesis of glycosyl carrier lipids required for protein glycosylation in the lumen of endoplasmic reticulum. Here, we report the crystal structure of the human NgBR/DHDDS complex, which represents an atomic resolution struct...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Edani, Ban H., Grabińska, Kariona A., Zhang, Rong, Park, Eon Joo, Siciliano, Benjamin, Surmacz, Liliana, Ha, Ya, Sessa, William C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456142/
https://ncbi.nlm.nih.gov/pubmed/32817466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2008381117
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