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A conserved C-terminal RXG motif in the NgBR subunit of cis-prenyltransferase is critical for prenyltransferase activity

cis-Prenyltransferases (cis-PTs) constitute a large family of enzymes conserved during evolution and present in all domains of life. In eukaryotes and archaea, cis-PT is the first enzyme committed to the synthesis of dolichyl phosphate, an obligate lipid carrier in protein glycosylation reactions. T...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Grabińska, Kariona A., Edani, Ban H., Park, Eon Joo, Kraehling, Jan R., Sessa, William C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5655512/
https://ncbi.nlm.nih.gov/pubmed/28842490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.806034
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