Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity

A tumor blood vessel is a key regulator of tissue perfusion, immune cell trafficking, cancer metastasis, and therapeutic responsiveness. mTORC1 is a signaling node downstream of multiple angiogenic factors in the endothelium. However, mTORC1 inhibitors have limited efficacy in most solid tumors, in...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Wang, Shan, Raybuck, Ariel, Shiuan, Eileen, Cho, Sung Hoon, Wang, Qingfei, Brantley-Sieders, Dana M., Edwards, Deanna, Allaman, Margaret M., Nathan, James, Wilson, Keith T., DeNardo, David, Zhang, Siyuan, Cook, Rebecca, Boothby, Mark, Chen, Jin
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7455083/
https://ncbi.nlm.nih.gov/pubmed/32759497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139237
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