Gene therapy for alpha 1-antitrypsin deficiency with an oxidant-resistant human alpha 1-antitrypsin

Alpha 1-antitrypsin (AAT) deficiency, a hereditary disorder characterized by low serum levels of functional AAT, is associated with early development of panacinar emphysema. AAT inhibits serine proteases, including neutrophil elastase, protecting the lung from proteolytic destruction. Cigarette smok...

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Detaylı Bibliyografya
Yayımlandı:JCI Insight
Asıl Yazarlar: Sosulski, Meredith L., Stiles, Katie M., Frenk, Esther Z., Hart, Fiona M., Matsumura, Yuki, De, Bishnu P., Kaminsky, Stephen M., Crystal, Ronald G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Clinical Investigation 2020
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7455074/
https://ncbi.nlm.nih.gov/pubmed/32759494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.135951
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