Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer

Previous studies found patients with POLE exonuclease domain mutations (EDMs) in targeted exons were related to significant better outcomes in stage II-III colorectal cancer (CRC). The detailed mutational profile of the entire POLE exonuclease domain, tumor mutation burden (TMB) and immune cell infi...

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Pubblicato in:J Immunother Cancer
Autori principali: Mo, Shaobo, Ma, Xiaoji, Li, Yaqi, Zhang, Long, Hou, Ting, Han-Zhang, Han, Qian, Juanjuan, Cai, Sanjun, Huang, Dan, Peng, Junjie
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMJ Publishing Group 2020
Soggetti:
Immunotherapy Biomarkers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454238/
https://ncbi.nlm.nih.gov/pubmed/32859741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000881
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