Somatic POLE exonuclease domain mutations elicit enhanced intratumoral immune responses in stage II colorectal cancer

Previous studies found patients with POLE exonuclease domain mutations (EDMs) in targeted exons were related to significant better outcomes in stage II-III colorectal cancer (CRC). The detailed mutational profile of the entire POLE exonuclease domain, tumor mutation burden (TMB) and immune cell infi...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Mo, Shaobo, Ma, Xiaoji, Li, Yaqi, Zhang, Long, Hou, Ting, Han-Zhang, Han, Qian, Juanjuan, Cai, Sanjun, Huang, Dan, Peng, Junjie
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Publishing Group 2020
Schlagworte:
Immunotherapy Biomarkers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454238/
https://ncbi.nlm.nih.gov/pubmed/32859741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-000881
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