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First total synthesis of the pro-resolving lipid mediator 7(S),12(R),13(S)-Resolvin T2 and its 13(R)-epimer

The first total synthesis of the pro-resolving lipid mediator 7(S),12(R),13(S)-Resolvin T2 [7(S), 12(R), 13(S)-RvT2] and its 13(R)-epimer, derived from n-3 docosapentaenoic acid (n-3 DPA), are described. 7(S), 12(R), 13(S)-RvT2 and its 13(R)-epimer were obtained by total synthesis using a chiral poo...

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Detalles Bibliográficos
Publicado en:Tetrahedron Lett
Main Authors: Rodriguez, Ana R., Spur, Bernd W.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454203/
https://ncbi.nlm.nih.gov/pubmed/32863450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2020.151857
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