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Effect of pre-freezing and saccharide types in freeze-drying of siRNA lipoplexes on gene-silencing effects in the cells by reverse transfection

Our previous study reported that reverse (Rev)-transfection with small interfering RNA (siRNA)/cationic liposome complexes (siRNA lipoplexes) freeze-dried in trehalose or sucrose solution resulted in high gene-silencing activity in cells. The current study investigated whether pre-freezing or saccha...

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Bibliographic Details
Published in:Mol Med Rep
Main Authors: Tang, Min, Hu, Subin, Hattori, Yoshiyuki
Format: Artigo
Language:Inglês
Published: D.A. Spandidos 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7453497/
https://ncbi.nlm.nih.gov/pubmed/32945442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2020.11419
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