Anti-α-synuclein ASO delivered to monoamine neurons prevents α-synuclein accumulation in a Parkinson's disease-like mouse model and in monkeys

BACKGROUND: Progressive neuronal death in monoaminergic nuclei and widespread accumulation of α-synuclein are neuropathological hallmarks of Parkinson's disease (PD). Given that α-synuclein may be an early mediator of the pathological cascade that ultimately leads to neurodegeneration, decrease...

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Publicado en:EBioMedicine
Autores principales: Alarcón-Arís, Diana, Pavia-Collado, Rubén, Miquel-Rio, Lluis, Coppola-Segovia, Valentín, Ferrés-Coy, Albert, Ruiz-Bronchal, Esther, Galofré, Mireia, Paz, Verónica, Campa, Leticia, Revilla, Raquel, Montefeltro, Andrés, Kordower, Jeffrey H., Vila, Miquel, Artigas, Francesc, Bortolozzi, Analia
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2020
Materias:
Research paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452525/
https://ncbi.nlm.nih.gov/pubmed/32810825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102944
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