Glyburide Regulates UCP1 Expression in Adipocytes Independent of K(ATP) Channel Blockade

Identification of safe and effective compounds to increase or activate UCP1 expression in brown or white adipocytes remains a potent therapeutic strategy to combat obesity. Here we reported that, glyburide, one of the FDA-approved drugs currently used to treat type 2 diabetes, can significantly enha...

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Udgivet i:iScience
Main Authors: Qiu, Yan, Yang, Yuanyuan, Wei, Yuda, Liu, Xiaojian, Feng, Zhuanghui, Zeng, Xuwen, Chen, Yanhao, Liu, Yan, Zhao, Yongxu, Chen, Lanlan, Luo, Lijun, Ding, Qiurong
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7452185/
https://ncbi.nlm.nih.gov/pubmed/32829287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101446
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