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Generation and characterization of keap1a- and keap1b-knockout zebrafish
The Keap1–Nrf2 pathway is an evolutionarily conserved mechanism that protects cells from oxidative stress and electrophiles. Under homeostatic conditions, Keap1 interacts with Nrf2 and leads to its rapid proteasomal degradation, but when cells are exposed to oxidative stress/electrophiles, Keap1 sen...
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| Publicado en: | Redox Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7452054/ https://ncbi.nlm.nih.gov/pubmed/32828016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101667 |
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