Deconvolving the contributions of cell-type heterogeneity on cortical gene expression

Complexity of cell-type composition has created much skepticism surrounding the interpretation of bulk tissue transcriptomic studies. Recent studies have shown that deconvolution algorithms can be applied to computationally estimate cell-type proportions from gene expression data of bulk blood sampl...

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Udgivet i:PLoS Comput Biol
Main Authors: Patrick, Ellis, Taga, Mariko, Ergun, Ayla, Ng, Bernard, Casazza, William, Cimpean, Maria, Yung, Christina, Schneider, Julie A., Bennett, David A., Gaiteri, Chris, De Jager, Philip L., Bradshaw, Elizabeth M., Mostafavi, Sara
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7451979/
https://ncbi.nlm.nih.gov/pubmed/32804935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008120
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