Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

BACKGROUND: The role of the innate immune system in Alzheimer’s disease (AD) and neurodegenerative disease susceptibility has recently been highlighted in genetic studies. However, we do not know whether risk for inflammatory disease predisposes unaffected individuals to late-life cognitive deficits...

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發表在:Mol Neurodegener
Main Authors: Felsky, Daniel, Patrick, Ellis, Schneider, Julie A., Mostafavi, Sara, Gaiteri, Chris, Patsopoulos, Nikolaos, Bennett, David A., De Jager, Philip L.
格式: Artigo
語言:Inglês
出版: BioMed Central 2018
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057096/
https://ncbi.nlm.nih.gov/pubmed/30041668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0272-6
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