Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

BACKGROUND: The role of the innate immune system in Alzheimer’s disease (AD) and neurodegenerative disease susceptibility has recently been highlighted in genetic studies. However, we do not know whether risk for inflammatory disease predisposes unaffected individuals to late-life cognitive deficits...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Felsky, Daniel, Patrick, Ellis, Schneider, Julie A., Mostafavi, Sara, Gaiteri, Chris, Patsopoulos, Nikolaos, Bennett, David A., De Jager, Philip L.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057096/
https://ncbi.nlm.nih.gov/pubmed/30041668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0272-6
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