Polygenic analysis of inflammatory disease variants and effects on microglia in the aging brain

BACKGROUND: The role of the innate immune system in Alzheimer’s disease (AD) and neurodegenerative disease susceptibility has recently been highlighted in genetic studies. However, we do not know whether risk for inflammatory disease predisposes unaffected individuals to late-life cognitive deficits...

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Publicado en:Mol Neurodegener
Autores principales: Felsky, Daniel, Patrick, Ellis, Schneider, Julie A., Mostafavi, Sara, Gaiteri, Chris, Patsopoulos, Nikolaos, Bennett, David A., De Jager, Philip L.
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6057096/
https://ncbi.nlm.nih.gov/pubmed/30041668
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-018-0272-6
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